Journal of Prevention, Diagnosis and Management of Human Diseases (JPDMHD) 2799-1202
https://journal.hmjournals.com/index.php/JPDMHD
<p>The <strong>Journal of Prevention, Diagnosis and Management of Human Diseases (JPDMHD)</strong> <strong>having ISSN:2799-1202</strong> is a double-blind, peer-reviewed, open access journal that provides publication of articles in all areas of Human Diseases and related disciplines. The objective of this journal is to provide a veritable platform for scientists and researchers all over the world to promote, share, and discuss a variety of innovative ideas and developments in all aspects of <strong>Human Diseases and related disciplines.</strong></p>HM Journalsen-USJournal of Prevention, Diagnosis and Management of Human Diseases (JPDMHD) 2799-12022799-1202The Relationship between the Prevalence of Cesarean Sections and Progesterone (Duphaston) Usage during Pregnancy
https://journal.hmjournals.com/index.php/JPDMHD/article/view/3700
<p>Background: Progesterone plays a crucial part in ovulation, implantation, and pregnancy, among other reproductive processes.This is related to progesterone's role in controlling cyclical changes in decidualization and proliferation, which regulate uterine function during the menstrual cycle. Progesterone is necessary for the development of decidual tissues. In the event of fertilization, high levels of progesterone in the blood are crucial for maintaining pregnancy by promoting uterine growth and inhibiting the effects of factors that cause myometrial contraction. During a cesarean section, the fetus is delivered via a surgical incision made in the woman's abdomen (laparotomy) and in her uterus (hysterotomy). The likelihood of experiencing health issues following a cesarean birth is somewhat increased due to the high number of caesarean sections performed globally in comparison to spontaneous births. Method: 65 pregnant women participated in this cross-sectional study, which ran from October 1, 2022, to March 20, 2023, in the gynecological department of Salah Al Deen General Hospital in the Salah al Deen governorate and in Diyala. Result: As in result of questioners in pregnancies take the progesterone as stabilizer About 75.4% of participants were delivered by cesarean section and only 24.6% were delivered by normal vaginal delivery . Conclusion: The regular use of progestagens for the treatment of impending miscarriage may have contributed to the increased rate of cesarean sections among the participants.</p>Zainab Mustafa Mahdi
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2024-02-222024-02-224021810.55529/jpdmhd.42.1.8Effectiveness of Proprioceptive Neuromuscular Facilitation Technique on Balance and Mobility in Chronic Stroke Patient
https://journal.hmjournals.com/index.php/JPDMHD/article/view/3702
<p>This comprehensive review explores the multifaceted impact of stroke, a cerebrovascular disorder, on individuals, emphasizing the physical, emotional, and cognitive dimensions of its aftermath. Stroke is a major global health concern, contributing significantly to mortality and disability. The immediate consequences involve neurological impairments such as paralysis, speech difficulties, and impaired vision, while the emotional toll includes coping with loss and adjusting to new realities. Long-term cognitive implications affect memory, attention, and executive function, adding complexity to the recovery journey. Communication challenges, physical limitations, and the risk of secondary complications are discussed, highlighting the importance of a continuum of care. The role of caregivers is explored, emphasizing the emotional, physical, and financial burdens they face. Technological innovations, such as virtual reality and robotics, are introduced as promising tools in stroke rehabilitation. The focus then shifts to balance and mobility issues in stroke survivors, particularly the impact of proprioceptive neuromuscular facilitation (PNF) techniques. Proprioceptive neuromuscular facilitation emerges as a dynamic and versatile therapeutic approach, offering promise for improved functional outcomes and enhanced quality of life in the evolving landscape of stroke care and rehabilitation. The review delves into the neurophysiological ballet of PNF, emphasizing neuromuscular stimulation, neuroplasticity, and motor learning. Clinical applications of PNF in orthopaedic, neurological, geriatric, and paediatric rehabilitation are discussed, highlighting its versatility.</p>Shreyash A. Manapure
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2024-02-232024-02-2340292010.55529/jpdmhd.42.9.20Correlation between Serum Levels of Progranulin and Spirometric Readings in Patients with Chronic Obstructive Pulmonary Disease
https://journal.hmjournals.com/index.php/JPDMHD/article/view/3752
<p>Back ground Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin ( PGRN ) is defined as precursor of pleiotropic glycosylated protein ,it have significant role in process of inflammation ,angiogenesis, neoplasia ,cell development ,cell cycle , embryogenesis, wound healing ,modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and spirometric readings in COPD patients. Patients and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: This study found that serum PGRN was elevated in cases of COPD more than controls (230.52±189.01 VS 114.19±68.41 ng/ml) there is significant association between PGRN and COPD ( P value 0.006 ) ,and found that PGRN negatively associated with FEV1 % ( P value 0.04 ) Conclusions:It was concluded that PGRN may be used as blood marker that indicate severity of airflow obstruction in COPD.</p>Fatima Ali AlkyoonFalah Mahdi Dananah
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2024-02-282024-02-28402212810.55529/jpdmhd.42.21.28Using Speckle Tracking Analysis, Does Age Affect RV Longitudinal Strain?
https://journal.hmjournals.com/index.php/JPDMHD/article/view/3754
<p>Introduction: The right ventricle (RV) is increasingly crucial in clinical settings, but traditional echocardiography is challenging to evaluate its function. Advanced techniques like speckle tracking improve RV functional assessment. According to previous studies, RV free wall longitudinal strain measurements vary with age necessitating further research. Aim: This study aimed to evaluate the effects of age on RV longitudinal strain using speckle tracking (ST) analysis. Methods: 103 healthy adult volunteers, mean age 37.1±11.9 years (range: 20-66), underwent comprehensive speckle tracking analysis, to determine age-related changes in RV dimensions and function. Results:showed a significant decrease in global and segmental (basal, mid, and apical) FWLS with age (p < .001). Conclusion: These significant differences in free wall longitudinal strains among age groups by 2D-ST analysis indicate the need for age-adjusted measures in RV function evaluation. Conventional techniques may ignore minor changes, leading to underestimated RV function assessment. The findings also suggest that advanced techniques allow early identification of RV dysfunction by detecting subclinical dysfunction before anomalies revealed by traditional echocardiography occur</p>Elham H. Manhal Al. ObaidiAsaad Hasan Noaman Al-Aboodi
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2024-02-282024-02-28402293810.55529/jpdmhd.42.29.38Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review
https://journal.hmjournals.com/index.php/JPDMHD/article/view/3819
<p>Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecular signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 and MALAT1 regulate apoptosis, inflammation, and fibrosis. Chronic kidney disease (CKD) involves lncRNAs like H19 and NEAT1 modulating cell proliferation and apoptosis. Beyond diagnostics, lncRNAs actively shape inflammation, apoptosis, and fibrosis, positioning them as master regulators in the intricate ballet of kidney health. Recent strides in research, coupled with cutting-edge genomics and bioinformatics tools, highlight their roles and therapeutic potential. Challenges in understanding their intricate roles and interactions necessitate the exploration of promising avenues, including single-cell RNA sequencing and artificial intelligence, paving the way for personalized interventions and regenerative medicine in kidney diseases.</p>Ramdas BhatPreeti Shanbhag
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2024-03-092024-03-09402395210.55529/jpdmhd.42.39.52