Formulation, Development and Evaluation of Herbal Transdermal Patches from Leaf Extract of Thespesia Populnea Linn. for Anti- Inflammatory Activity

Abstract

The Thespesia Populnea Linn are large trees belonging to the Malvaceae family. It is a tiny, evergreen tree with a broad, heavy crown and a short, frequently twisted stem that grows to an average height of 6 to 10 metres [20 to 33 feet]. It features yellow hibiscus-like flowers and glossy green, heart shaped leaves. Thespesia populnea has a wide variety of active chemical ingredients, traditional applications, photochemistry, and pharmacology for drug development research. The plant contain a broad variety of biologically active substances, including sugars, antioxidants, tannins, sesquiterpenoids, flavonoids, alkanes, and essential oils. It is known that different plant parts, such as the roots, bark, leaves, flowers, and fruits, have distinct pharmacological characteristics such as anti-diarrheal, anti-microbial, anti-diabetic, memory boosting antibacterial and antioxidant, anti-inflammatory, wound healing activity. One non-invasive way to administer medication is via transdermal patches. It's an adhesive patch that works by putting a predetermined amount of medicine under the skin and into the body's bloodstream. Transdermal medication delivery has a number of benefits over conventional delivery methods, including the ability to avoid first-pass metabolism and the harmful acidic environment of the stomach that arises when pharmaceuticals are taken orally. It is also more patient-friendly. The patches were assessed using physicochemical criteria, including pH, flatness, moisture absorption, drug content, thickness, folding endurance, physical appearance, weight uniformity, moisture content, and an in-vitro drug release and stability study.