Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals

https://doi.org/10.55529/jhtd.12.12.19

Authors

  • Zafar Isomiddinovich Sanoev Academy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
  • Tolmas Tolibovich Khamroev Academy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
  • Ibrokhim Tuychievich Abdinazarov Academy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
  • Sokhib Zamon ugli Rashidov Academy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
  • Sukhrob Davlatyor ugli Rakhimboev Academy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan

Keywords:

Allapinine, N-Deacetylappaconitine, Corazole, Strychnine, Isoniazid, Antiarrhythmic, Kidling, Lappaconitine

Abstract

The present article presents a research paper on the evaluation of anticonvulsant activity of allapinine and N-debacetylappaconitine with high antiarrhythmic activity caused at different doses and with different analyzers. The results of the conducted studies showed that allapinine and N-debacetylappaconitine are not inferior and even slightly superior to carbamazepine in anticonvulsant activity. In this regard, based on the conducted studies, it can be concluded that allapinin affects not only cardiomyocytes, but also ion exchange in nerve cells.

Published

2021-11-22

How to Cite

Sanoev, Z. I. ., Khamroev, T. T. ., Abdinazarov, I. T. ., Rashidov, S. Z. ugli ., & Rakhimboev, S. D. ugli . (2021). Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals. Journal Healthcare Treatment Development, 1(02), 12–19. https://doi.org/10.55529/jhtd.12.12.19