In-Depth Evaluation of Serum Ferritin and Iron Concentrations in Individuals Suffering from Major Thalassemia in the Urban Settings of Kirkuk City: An Elaborate Clinical Study

Abstract

Background Thalassemia major is a major health problem since it is linked with chronic anemia and the danger of iron overload from repetitive blood transfusions. This investigation aims at the relation of serum ferritin with iron indices in major thalassemic patients in Kirkuk in order to enhance credential of these biomarkers in optimization of management and patient care.Methodology: This was a cross-sectional study of 40 patients of 12 to 40 years with a diagnosis of major thalassemia, and who attended a specialized center in Kirkuk. The study focused on participants with a known diagnosis and a treatment that involved regular blood transfusion. The serum ferritin and iron levels were determined and complex statistical analyses were used to define the association between these parameters.Results: A positive correlation of serum ferritin was found with iron levels in the subjects. This correlation draws attention to the thin border line between iron load from transfusions and iron storage systems in the body, and therefore, shows that one should closely control the quantity of iron in patients with Thalassemia major.Discussion: The Result provides the clear need to carry out constant performance and supervision of ferritin serum as well as iron serum in a manner that is appropriate accompanied by appropriate tests and evaluations for the future treatment. Thus, emergence of early diagnosis before iron overload occurs, and possibility of treatment of it are of the utmost importance. The perfect example of the individualized approach will be the ready customization of the chelation therapy taking into account the particular features of the case. It is therefore maybe even possible to do something to prevent the risks that might accompany HH. These risks are connected with the inheritance of haemochromatosis, the mechanism that is responsible for the excessive iron overload.Conclusion: In general, it is confirmed by this study that serum ferritin and iron levels tests play an essential role in developing personalized treatment schemes of severe thalassemia patients. It is a patient centred care model of coordination with a multidisciplinary team for optimal iron balance, improving patient’s health outcomes and quality of life.