Dynamic Changes of Cytokines in the Occurrence of Chronic Liver Damage in an Experimental ConditionDynamic Changes of Cytokines in the Occurrence of Chronic Liver Damage in an Experimental Condition

Abstract

This article presents the characteristics of liver fibrosis in rats with chronic heliotrin intoxication, indicators characteristic of the formation of animal serum fibrosis, an increase in the level of inflammatory-stimulating cytokines IL-1ß, IL-2, IL-6 and IL-17 was observed in dynamics. Induction of cytokines IL-1ß, Il-2, IL-6 and IL-17 was detected in the dynamics of the development of experimental heliotrine hepatitis, the maximum increase in their number was established on the 35th day of the development of heliotrine hepatitis compared with intact animals. Thus, in studies, profound changes in the immunoregulatory function of cytokines were observed as the lesion process intensified in experimental chronic hepatitis. These changes were especially evident in Anna as the disease progressed. From the conducted studies, it can be concluded that an important topical issue is the identification and correction of liver damage processes at the earliest possible stages.