Estimation of LCAT and Some Oxidative Stress in Type 2 Diabetic Patients in Kirkuk, Iraq

Abstract

This study is the first to be conducted in Kirkuk City in terms of linking antioxidant parameters with the LCAT enzyme in type 2 diabetes patients. Oxidative stress has received a lot of attention in the field of human health, notably because of its link to diabetes. Oxidative stress is a state in which there is an imbalance between the creation of reactive oxygen species (ROS) and the ability of the body's antioxidant defense system to neutralize them. The purpose of this study was to evaluate the effect of LCAT and various biochemical parameters that were deemed oxidative stress indicators in patients with type II diabetes compared with normal healthy controls in Kirkuk City - Iraq. This study comprised 184 individuals (128 Type 2 diabetic mellitus (T2DM) patients and 56 healthy controls) ranging in age from 40 to 80 years old for both patients and controls. This study was divided into two groups of T2DM patients based on their HbA1c levels, which allude to the patient's diabetes control. The first group (G1) (70 instances) included patients whose HbA1c level was higher than 7% (poorly controlled or uncontrolled) and The second group (G2) contained individuals with HbA1c levels less than 7%, which included 58 instances compared to 56 healthy controls (G3). There was a significant decrease in PON1, LCAT, and NO in DM patients (G1, G2) compared with control groups (G3) (P-Value = 0.01). As well as Glutathione peroxidase and Melatonin significantly decreased in DM patients (G1, G2) compared with control groups (P-Value = 0.02, 0.03 respectively). While MDA was significantly increased in DM patients (G1, G2) when compared with the control group (P-Value 0.011).