Evaluation of Some Immunological Parameters against Streptococcus Pyogenes in Tonsillitis

Authors

  • Nebras Ayad Mohammed Department of Biology, College of Science, Tikrit University, Tikrit, Iraq.
  • Sundus Jassim Muhammad Department of Biology, College of Science, Tikrit University, Tikrit, Iraq.
  • Abdulwadood Shakir Mahmood Alsoufi Department of Biology, College of Science, Tikrit University, Tikrit, Iraq.

Keywords:

Tonsillitis, TNF-Α, Antistreptolysin O Titer, IL-10

Abstract

This study was designed to evaluate some immunological parameters in patients with chronic tonsillitis. Swabs were obtained from the tonsils of 120 patients with chronic tonsillitis to detect streptococcus pyogenes and. and blood samples collected to detect the immune parameters in the patient's serum. The results of culture showed that 60 samples (50%) were positive to streptococcus pyogenes. Significant differences were observed in ASO titer levels between the tonsillitis group (400 IU, interquartile range: 400-1600) and the control group (200 IU, interquartile range: 0), with a p-value <0.05. However, no statistically significant differences were observed in TNF-α levels between the two groups, with a median of 248 pg/ml (interquartile range: 125) in the tonsillitis group and 209 pg/ml (interquartile range: 112) in the control group (p>0.05). Nevertheless, a significant decrease in IL-10 levels was observed in the tonsillitis group (51.8 pg/ml, interquartile range: 29.4) compared to the control group (81.4 pg/ml, interquartile range: 36.4), with a p-value <0.05.

Published

2024-04-11

How to Cite

Nebras Ayad Mohammed, Sundus Jassim Muhammad, & Abdulwadood Shakir Mahmood Alsoufi. (2024). Evaluation of Some Immunological Parameters against Streptococcus Pyogenes in Tonsillitis. Journal of Prevention, Diagnosis and Management of Human Diseases (JPDMHD) 2799-1202, 4(03), 27–32. Retrieved from https://journal.hmjournals.com/index.php/JPDMHD/article/view/4040